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3D printing of hydrogel scaffolds for future application in photothermal therapy of breast cancer and tissue repair
Yongxiang Luo ⇑, Xiaoyue Wei, Yilin Wan, Xin Lin, Zhiyong Wang, Peng Huang ⇑ Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518060, China
Surgical removal remains the main clinical approach to treat breast cancer, although risks including high local recurrence of cancer and loss of breast Seladelpar are the threats for the survival and quality of life of patients after surgery. In this study, bifunctional scaffold based on dopamine-modified alginate and poly-dopamine (PDA) was fabricated using 3D printing with an aim to treat breast cancer and fill the cavity, thereby achieving tissue repair. The as-prepared alginate-polydopamine (Alg-PDA) scaffold exhibited favorable photothermal effect both in vitro and in vivo upon 808 nm laser irradiation. Further, the Alg-PDA scaffold showed great flexibility and similar modulus with normal breast tissues and facilitated the adhesion and proliferation of normal breast epithelial cells. Moreover, the in vivo performance of the Alg-PDA scaffold could be tracked by magnetic resonance and photoacoustic dual-modality imaging. The scaffold that was fabricated using simple and biocompatible materials with individual-designed structure and macropores, as well as outstanding photothermal effect and enhanced cell proliferation ability, might be a potential option for breast cancer treatment and tissue repair after surgery.
Statement of Significance
In this study, a three-dimensional porous scaffold was developed using 3D printing for the treatment of local recurrence of breast cancer and the following tissue repair after surgery. In this approach, easily available materials (dopamine-modified alginate and PDA) with excellent biocompatibility were selected and prepared as printing inks. The fabricated scaffold showed effective photothermal effects for cancer therapy, as well as matched mechanical properties with breast tissues. Furthermore, the scaffold sup-ported attachment and proliferation of normal breast cells, which indicates its potential ability for adi-pose tissue repair. Together, the 3D-printed scaffold might be a promising option for the treatment of locally recurrent breast cancer cells and the following tissue repair after surgery.
2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Breast cancer remains the major cause of the high mortality among women worldwide . Currently, surgical treatment remains the standard clinical therapy of breast cancer. Particularly, breast-conserving therapy has attracted increasing attention and become the primary surgical approach for the treatment of breast cancer . However, there are some issues with patients after sur-gery including the high local recurrence rate of breast cancer and partial loss of the breast tissues . Currently, chemotherapy and
⇑ Corresponding authors.
E-mail addresses: [email protected] (Y. Luo), [email protected] (P. Huang).
radiotherapy are the two classic therapeutics to address cancer recurrence after surgical treatment, while they usually cause sev-ere side effects [4,5]. On the other hand, near-infrared (NIR) light-induced photothermal therapy (PTT) is a burgeoning and minimally invasive cancer therapeutic approach to kill cancer cells by hyperthermia [6,7]. Therefore, there is high demand for the development of multifunctional scaffolds with desirable pho-tothermal conversion ability to overcome the risk of local cancer recurrence and realize the reconstruction of breast tissues simultaneously.