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br Fig Combined treatment with AC
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Fig. 4. Combined treatment with AC and TRAIL triggers caspase-independent apoptosis in RC-58T/h/SA#4 cells. (A) Cells were pretreated with 2 μM N-phenylmaleimide (N-PM), an AIF inhibitor, for 2 h and then incubated with AC and/or TRAIL for 24 h. Cell viability was determined by SRB assay. (B) Afte
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br Protein degradation in the cell is mainly
2022-06-21
Protein degradation in the cell is mainly performed by the ubiquitin-proteasome system (UPS) and the autophagy-lysosome pathway. In the UPS, proteins labeled by a chain of ubiquitin are recognized and then degraded by the 26 S proteasome consisting of a 19S regulatory particle Corresponding aut
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br Lohinai Z Klikovits T Moldvay J Ostoros G
2022-05-30
[31] Lohinai Z, Klikovits T, Moldvay J, Ostoros G, Raso E, Timar J, Fabian K, Kovalszky I, Kenessey I, Aigner C, Renyi-Vamos F, Klepetko W, Dome B, Hegedus B. KRAS-mutation incidence and prognostic value are metastatic site-specific in lung adenocarcinoma: Poor prognosis in patients with KRAS Cetu
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br prostate cancer which might result in suboptimal cancer
2022-05-30
prostate cancer, which might result in suboptimal cancer con-trol.14,15 An additional advantage of our analysis is that all patients were treated with RP, minimizing any potential confounding effect of differing treatment modalities. The exact mechanisms underlying the link between low SES and
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br In conclusion these hypothesis generating findings support further consideration
2022-05-30
In conclusion, these hypothesis-generating findings support further consideration of adjuvant regimens that include the delivery of CT be-fore RT. For women with locally advanced Type 1 EC, treatment with multi-agent CT before RT (or potentially employing a sandwich ap-proach) may optimize control
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br The CARDIA longitudinal study from
2022-05-25
The CARDIA longitudinal study from 1985 to 2011 reported that age at baseline was associated with the failure to quit smoking by the end of the study, and more relapse was observed among those who gave up smoking16; 18-24 years old vs 25-30 years old, always smoked 30.1% vs 23.1% and unsuccessful
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aThe P value from the
2022-05-23
aThe P value from the t test of the PSA numbers between prostate cancer and control groups. Data Processing and Statistical Analysis We used Mirex as the internal standard because of its nonexis-tence in human urine. The relative intensity of each VOC peak could then be normalized against that
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br Therefore through the application of
2022-05-23
Therefore, through the application of dynamic magnetic reso-nance imaging in breast cancer adjuvant chemotherapy, dynamic enhanced magnetic resonance imaging can accurately evaluate the neoadjuvant chemotherapy of breast cancer from the microscopic molecular level, and can reflect the microvascula
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br Fund Key Program of Natural Science Research
2022-05-23
Fund: Key Program of Natural Science Research of Higher Education of Anhui Province (No. KJ2017A241), the National Natural Science Foundation of China (No. 81772493). © 2019 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/lice
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br Tumours were harvested homogenized and the levels
2022-05-23
Tumours were harvested, homogenized, and the levels of down-stream protein targets of the drug were analysed using western blotting to further examine target modulation in vivo. As shown in Fig. 6, the level of the epithelial marker E-cadherin was increased, while the levels of the mesenchymal mar
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br Fig Immune cell population T cell polarization and the
2022-05-20
Fig. 6. Immune-cell population, T-cell polarization, and the expression levels of Treg-related and anti-inflammatory cytokine genes in the spleen. The profile of immune cells such as dendritic cells, macrophages, NK cells, CD4+ cells, CD8+ cells, and Tubercidin was determined (A–F). In addition,
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br Discussion br Tumor metastasis requires cell
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5. Discussion Tumor metastasis requires cell migration. HDAC6 possesses two catalytically active domains and deacetylates highly abundant sub-strates, such as Hsp90 and cortactin, to mediate diverse and complex pathways related to both cytoskeleton remodeling and cell migration. These mediatory
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br ACCEPTED MANUSCRIPT br brushings
2022-05-18
ACCEPTED MANUSCRIPT brushings [26]. An advantage of ERCP guided sampling is the lack of tumor seeding, a known risk described in EUS/FNA patients [20, 27]. There is a growing body of literature about the epigenetic molecular markers, microRNAs (miRs), which can be utilized in clinical applic
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br The model system br The model
2022-05-18
2. The model system The model is formulated on the basis of the model in [37]. Let X1 and X2 be the concentrations of androgen-dependent cells and androgen-independent cells respectively, and let A be the concentration of androgen in the blood. To separate the influence of stochastic noise from
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br caption on next page
2022-05-15
(caption on next page) Fig. 4. Identification of enriched miRNA Prostaglandin E2 from mRNA-miRNA and lncRNA-miRNA interaction networks and stage specific mRNA-miRNA-lncRNA association network generation. miRNA-mRNA interaction networks are being depicted for miRNA family enrichment of validate